Rnf145
WebDec 8, 2024 · Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. Jiang LY, Jiang W, Tian N, Xiong YN, Liu J, Wei J, Wu … WebTogether with the previous findings that Rnf145 is an LXR-regulated gene and that RNF145 inhibits the SREBP pathway through ubiquitinating SCAP, RNF145 serves as an important …
Rnf145
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WebDec 13, 2024 · In particular, RNF145 builds up when a cell is starved of cholesterol, but it immediately marks HMGCR for destruction once cholesterol becomes more abundant. … WebNM_001199383.2(RNF145):c.1297T>A (p.Leu433Ile) Cite this record. Cite this record Close. Copy. Help Interpretation: Uncertain significance Review status: criteria provided, single submitter Submissions: 1 First in ...
WebAug 22, 2024 · RNF145's auto-ubiquitination and degradation are potently inhibited by unsaturated FAs (oleic, arachidonic or eicosapentaenoic acids), allowing RNF145 to … WebApr 8, 2024 · Somatic mutations in non-coding regions of the genome and even exonic mutations may have unidentified non-coding consequences which are often overlooked in analysis workflows. Here we present RegTools ([www.regtools.org][1]), a free, open-source software package designed to integrate analysis of somatic variant calls from genomic …
WebHuman pathology. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. RNF145. WebThe gene view histogram is a graphical view of mutations across RNF145. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.
WebJul 21, 2015 · Consequently, ablation of Rnf145 in murine macrophages enhances bacterial clearance, and rescues the oxidative burst defects associated with Ncf4 haploinsufficiency.
WebQ96MT1 - RNF145 - RING finger protein 145 - Exons. E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. … paroles de set fire to the rainWebThe sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. elife. 2024;7: pubmed publisher . product … paroles de rick astley together foreverWebThe gene view histogram is a graphical view of mutations across RNF145. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict … timothy eigo teaneck njWebOct 27, 2024 · Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels. Conversely, … paroles de la chanson the sound of silenceWebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RNF145 antibody (ab122348) ab122348, at a 1/700 dilution, staining RNF145 in paraffin … paroles de precious thingWebFeb 23, 2024 · Regulation of RNF145 by LXR depends on a functional LXR-element in its proximal promotor. Consistent with LXR-dependent regulation of Rnf145 we show that … timothy e irvine mdWebOur RNF145 polyclonal antibodies are developed in Rabbit. Find the RNF145 antibody that fits your needs. Choose from 1 of 2 RNF145 antibodies, which have been validated in … paroles de shining light