WebTrimethylsilyl Cyanide – A Reagent for Umpolung, V. Nucleophilic Acylation of Alkylating Reagents with α,β-Unsaturated Aldehydes. The readily accessible adducts 3 from α,β-unsaturated aldehydes and trimethylsilyl cyanide react smoothly after deprotonation (LDA) as anions 3 A with different alkylating agents in 1-position. Removal of the protective … WebTrimethylsilyl cyanide (TMSCN) can be used as a reagent in the: Cyanosilylation of carbonyl compounds using various catalysts. Synthesis of α-aminonitriles by one-pot, three-component Strecker reaction of ketones with various amines using Brønsted acid catalyst. Cyanation of aryl halides using palladium-complex as a catalyst.
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WebA general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ke WebTrimethylsilyl cyanide Revision Date 30-Oct-2014 R-phrase(s) R11 - Highly flammable R29 - Contact with water liberates toxic gas R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the how many weeks until 11 jan
European Journal of Organic Chemistry
WebActivation of trimethylsilyl cyanide and mechanistic investigation for facile cyanosilylation by solid acid catalysts under mild and solvent-free conditions. Applied Catalysis A: General 2010 , 384 (1-2) , 147-153. WebShop Trimethylsilyl cyanide, 98%, AcroSeal™, Thermo Scientific Chemicals at Fishersci.com Trimethylsilyl cyanide, 98%, AcroSeal , Thermo Scientific Chemicals, Quantity: 100 mL … WebApr 17, 2024 · In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which … how many weeks until 1/17/2023